For many reasons, there are many drugs that are being used for the treatment of erectile dysfunction. However, when it comes for the treatment done through different routes and the introducing the medicine in the body, this is where the difference starts. For many cases of medicines used, there is the barrier of the first pass metabolism done by liver. All of the drugs that are taken orally pass through liver, however, for the medications that are being used intravenously, sublingually or topically, there are minimal chances that it will pass through the liver, hence, increasing the bio-availability of the drug. Same was suggested by the 104th annual meeting of American Urological Association which states that the medications for erectile dysfunction shall be used for the treatment topically. In this annual meeting, the use of the Nanoparticles availability theory was also suggested and it was decided that it will be put to test for the treatment and the increase bio-availability of erectile dysfunction medicines.

Hence, the first step is taken for accomplishment for the gold standard medication for the erectile dysfunction. Some of the people think that Viagra is the best for them, while on the other hand, the team of researchers in New York started investigating that how the topical, glass, or hydrogel application for the drug of erectile dysfunction can done through the use of Nanoparticles. The basic aim of this therapy induction is the use of these Nanoparticles which will make the increase bio-availability of the nitric oxide to the penis tissues. Nitric oxide has been established in the medical setups and the pharmaceutical companies which are considered to be one of the major compounds released in the body which will dilate the vessels in the body. Not only it is being manufactured as the anti angina drug for the treatment of stable and unstable angina, but it has also shown the great effects on the dilation of the penis vessels.

However, there is one problem that has been faced by the researchers. Once, nitric oxide enters in the body, it is soon degenerated. Hence, most of its compounds are produced in the stable forms. Therefore, the production of the nitric oxide in the Nanoparticles packets is in the trial phase. Phase I has been completed, where the application of the these Nanoparticles packets has shown the positive results on the rats, however, the human trials are still awaiting the orders from FDA, yet, it is believed, that it will show the promising results.